First listed on: 24 November 2021

CSIRO Postdoctoral Fellowship Protein Bioconjugation Chemistry


Acknowledgement of Country

CSIRO acknowledges the Traditional Owners of the land, sea and waters, of the area that we live and work on across Australia. We acknowledge their continuing connection to their culture and pay our respects to their Elders past and present. View our vision towards reconciliation.

The Opportunity

  • Do you have a PhD in chemistry?
  • Do you have expertise in synthetic organic chemistry, antibody bioconjugation, protein modification and protein purification?
  • Join an international, multi-disciplinary research team within our Manufacturing Business Unit in this exciting postdoctoral role

CSIRO Early Research Career (CERC) Postdoctoral Fellowships provide opportunities to scientists and engineers who have completed their doctorate and have less than three years of relevant postdoctoral work experience. These fellowships aim to develop the next generation of future leaders of the innovation system.

CSIRO Manufacturing is seeking to appoint a highly motivated Postdoctoral Fellow into the Biomedical Manufacturing Program in bioconjugation chemistry; working at the intersection of organic and protein chemistry, based in Melbourne.

The Postdoctoral Fellow will join our team which has expertise in synthetic chemistry; protein engineering; bioconjugation chemistry; ex vivo models and cell lines; and biotherapeutic data analysis programming and protein mass spectrometry. The team spans CSIRO's Manufacturing and Health & Biosecurity business units, working with the Australian Centre for Disease Preparedness. The project is strengthened by collaboration with an international biotherapeutic analysis company (USA), and through an established partnership with the Queensland University of Technology. The team will provide the Postdoctoral Fellow with a sophisticated research environment to independently drive this research project.

The Postdoctoral Fellow will be directly responsible for the design and development of new efficient processes for the synthesis of therapeutically impactful, antibody-drug-conjugates. Development of these bioconjugate systems will immerse the Postdoctoral Fellow in cutting edge, world-class science that will be instrumental in creating an outstanding scientific research project.

Your duties will include:

  • Applying organic chemistry, bioconjugation chemistry and protein chemistry to design a program of work to deliver novel antibody-drug-conjugates.
  • Developing new methods to optimise conjugation chemistry, isolation, and characterisation of the conjugates using LC-MS analytics software.
  • Carrying out innovative, impactful research of strategic importance to CSIRO that will, where possible, lead to novel and important scientific outcomes.
  • Recognising and exploiting opportunities for innovation and the generation of new theoretical perspectives, and progress opportunities for the further development or creation of new lines of research.
  • Utilising design thinking methodology to plan and prepare research proposals, and applying non-academic impact methodology to research projects. 

Location: Clayton, Victoria
Salary: AU$89k - AU$98k plus up to 15.4% superannuation
Tenure: Specified term of 3 years
Reference: 79543

To be considered you will need:

  • A doctorate (or will shortly satisfy the requirements of a PhD) in a relevant discipline area, such as chemistry. Please note: To be eligible for this role you must have no more than 3 years (or full-time equivalent) of postdoctoral research experience.
  • Demonstrated expertise in synthetic chemistry.
  • Demonstrated ability to perform protein chemistry, purification, and analysis.
  • Demonstrated ability to perform bioconjugation of small molecules to proteins, including purification and analytical methods.
  • The ability to work effectively as part of a multi-disciplinary, research team, plus the motivation and discipline to carry out autonomous research.

For full details about this role please view the Position Description


To be eligible for this role, you must be an Australian/New Zealand Citizen, Australian Permanent Resident or Australian temporary resident currently residing in Australia and be able to commence in the role by 30 June 2022.

The successful applicant will be required to obtain and provide a National Police Check or equivalent. Additional integrity checks may be required for specific roles which require security clearance for working with children, Australian Government cybersecurity requirements or other identified security roles.

Flexible Working Arrangements

We work flexibly at CSIRO, offering a range of options for how, when and where you work. 

Diversity and Inclusion

We are working hard to recruit people representing the diversity across our society, and ensure that all our people feel supported to do their best work and feel empowered to let their ideas flourish. 


At CSIRO Australia's national science agency, we solve the greatest challenges through innovative science and technology. We put the safety and wellbeing of our people above all else and earn trust everywhere because we only deal in facts. We collaborate widely and generously and deliver solutions with real impact. 

Join us and start creating tomorrow today!

How to Apply

Please apply on-line and provide a cover letter and CV that best demonstrate your motivation and ability to meet the requirements of this role.

Applications Close

30 January 2022, 11:00pm AEDT

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