The Australian Medical Association has called for new management at Princess Margaret Hospital (PMH).

The PMH Clinical Staff Association says the hospital is struggling with a shortage of registrars, a lack of after-hours services, limitations on taking leave and low morale.

Andrew Miller, WA president of the Australian Medical Association (AMA), says the issues are not new.

‘This isn't new, the staff there have been making their concerns known to the executive for some time now, but the executive are really treating them with contempt unfortunately,” Dr Miller told the ABC.

“There either needs to be a dramatic change of attitude and the way they're running things or we need to give somebody else a chance to run it in a way that is sustainable.

“In a way that provides decent after-hour levels, that provides proper staffing levels so that people who are working there don't get burned out.”

Dr Miller said the situation is nearing a breaking point, with senior doctors threatening to jump ship.

“You've got people getting promoted to positions above their level of experience, because the experienced people are voting with their feet and they're getting away from PMH at the moment,” he said.

PMH has had to stay open while delays continue at the new Perth Children's Hospital.

But Dr Miller says opening the new site will not solve the problems at the old one.

“We're worried that these are the same people that are going to be charged with the new hospital as well,” he said.

Premier Colin Barnett denies PMH is facing a crisis.

“There's no doubt that PMH is facing some pressure because we already have around 200 to 300 Health Department and hospital staff in the new hospital,” he said.

“They're working there now so they're stretched across two sites so that's clearly making it difficult and that's why I, and I think everyone, is frustrated at the delay in moving into the new hospital.”